Dexsol™
Dexsol is an injectable dextran gel that is used in the bladder to stop urine backflow from the bladder to the kidneys in children with a condition known as Vesico-Ureteral Reflux (or VUR). Its effectiveness and stability have been approved from KFDA and its insurance coverage reduces cost bearing of patients with the latest treatment for VUR.
Characteristics of product
Easy to handle
References:
1. Lackgren G, Lottman H, Hensle T, Stenberg A. Endoscopic treatment of vesioureteral reflux and urinary incontinence in children. AUA Update Series. 2003;22:294-299.
2. Lottmann HB, Margaryan M, Bernuy M, et al. The effect of endoscopic injections of dextranomer based on continence and bladder capacity: a prospective study of 31 patients. J Urol. 2002; 168:1663-1867.
3. Capozza N, Lais A, Matarazzo E, Nappo S, Patricolo M, Caione P. Treatment of vesico-ureteric reflux: a new algorithm based on parental preference. BJU International. 2003;92:285-288.
4. Capozza N, Caione P. Dextranomer/hyaluronic acid copolymer implantation for vesico-ureteral reflux: a randomized comparison with antibiotic prophylaxis. J Pediatr 2002; 140: 230-4.
5. Andrew J. Kirsch, Hal C. Scherz, at al. Hydro-distention implantation technique (HIT)-a novel endoscopic treatment for VUR in children and adults Contemporary Urology, April 2005.
Effectiveness & stability
“Dextran is verified its effectiveness and stability by clinical trials”
The facts that reflux may persist for a number of years provide the rationale for treating VUR. Research result was published number of times for more than ten years and more than 100,000 children were cured by VUR treatment with dextran. There was no such thing was continuous adverse effect.
The VUR treatment using dextran is suitable treatment for children who are suffering with vesicoureteral reflux (VUR) by fast checkup and preventing damage of kidney.
References:
1. Capozza N, Caione P. Dextranomer/hyaluronic acid copolymer implantation for vesico-ureteral reflux: a randomized comparison with antibiotic prophylaxis. J Pediatr 2002; 140: 230-4.
2. Sjostrom S, Sillen U, Bachelard M, et al. Spontaneous resolution of high grade infantile vesicoureteral reflux. J Urol 2004; 172: 694-8.
Mechanism
Dextran tissue reaction
Dexol forms a large amount of collagen tissue around dextran particles. And, the raw material, dextran, biodegrades within 1 to 2 years. Prolonged fixation and volume effect by proliferated collagen tissue It has the characteristic of being maintained for a long time.
A New blood vessels
B Macrophase
C Dextran
D Newly generated collagen (TypeⅠ& TypeⅢ)
Collagen capsule formation tissue reaction
A collagen capsule is created around the injected dextran. In addition, the inside of the capsule is also filled with collagen tissue. It remains in the state of a collagen implant.
※ Dextran particles within the collagen capsule (A) without tissuereaction stays safe.
